Premier Research Labs progesterone cream is a topical botanical formula for balance support. Learn ingredients, how to use it, safety notes, and where to buy.
Premier Research Labs Progesterone Cream is a topical, paraben-free formula that combines wild yam extract with moisturizing botanicals to support the body’s natural hormone balance. It is sold as a dietary supplement or cosmetic cream, not as an FDA-approved drug, so it is not intended to diagnose, treat, cure, or prevent any disease. Most users apply a small amount to thin-skinned areas such as the wrists, inner arms, or thighs.
What Is Premier Research Labs Progesterone Cream?
Premier Research Labs (PRL) is a Texas-based supplement company founded by Dr. Bob Marshall. The brand focuses on botanical, whole-food, and practitioner-grade products. Its progesterone cream is designed for topical use and is free from parabens, synthetic fragrances, and other common cosmetic additives.
The cream is not a standardized hormone medication. Instead, it uses wild yam root extract (Dioscorea villosa), which contains diosgenin, a plant compound that some believe may support progesterone balance when applied to the skin. The label may also list ingredients like shea butter, jojoba oil, and vitamin E to nourish the skin.
Because the FDA does not evaluate over-the-counter progesterone creams for safety or effectiveness, you should treat this product as a wellness supplement rather than a medical treatment.
Key Ingredients and How the Cream Works
Here is a quick look at the typical ingredients in Premier Research Labs Progesterone Cream and what they do.
| Ingredient | Typical Role |
|---|---|
| Wild yam root extract | Plant source of diosgenin, often marketed for hormone balance support |
| Shea butter or jojoba oil | Moisturizing base that helps the cream spread easily |
| Vitamin E | Antioxidant that helps preserve the formula |
| Aloe vera or glycerin | Soothing and hydrating agents |
Some people ask whether topical progesterone can be absorbed through the skin. Research suggests that small amounts of hormones can pass through the skin, but absorption varies widely by person, application site, and formula. The cream is not designed to deliver a precise, measurable dose.
If you are looking for other PRL products, many shoppers also compare premier research labs colostrum cream for skin and immune support, or premier research labs castor oil for topical packs and massage.
How to Use Premier Research Labs Progesterone Cream
Follow the label directions, but most users apply a quarter-teaspoon or a small pump once or twice daily. Here is a typical routine:
- Wash and dry the application area.
- Apply a thin layer to thin-skinned areas such as the inner wrists, inner arms, thighs, or behind the knees.
- Rotate the application site each day to avoid skin irritation.
- Use for three weeks, then take one week off, unless a healthcare provider says otherwise.
Do not apply the cream to broken skin, the face, or the breasts unless a doctor tells you to. Wash your hands after use. If you are also using other topical products, wait a few minutes between applications.
Safety, Side Effects, and Who Should Avoid It
Premier Research Labs Progesterone Cream is generally well tolerated, but it is not right for everyone. Possible side effects include:
- Skin redness, itching, or rash at the application site
- Breast tenderness
- Mood changes, headaches, or bloating
- Changes in menstrual bleeding
Talk to a healthcare professional before using this cream if you are pregnant, nursing, or have a history of hormone-sensitive conditions such as breast, uterine, or ovarian cancer. People taking hormone replacement therapy, birth control, or thyroid medication should also check for interactions.
Do not use this product on children or pets. Keep it out of reach of children. If you experience severe or unusual symptoms, stop using it and seek medical advice.
Important: The FDA has not approved over-the-counter progesterone creams to treat menopause symptoms, infertility, or any other medical condition.
How It Compares to Other Premier Research Labs Products
Premier Research Labs makes a wide range of supplements, and it helps to see how the progesterone cream fits into the lineup. The table below compares five popular PRL products.
| Product | Primary Use | Form |
|---|---|---|
| Premier Research Labs Progesterone Cream | Topical hormone balance support | Cream |
| premier research labs parastat | Gastrointestinal and immune support | Capsules |
| premier research labs creatine | Muscle and energy support | Powder |
| premier research labs gold-360 | Broad-spectrum immune support | Liquid |
| Colostrum Cream | Skin and immune support | Cream |
As you can see, each product targets a different system. The progesterone cream is unique because it is applied to the skin and is marketed for hormone balance, while most other PRL products are taken orally. If you are unsure which product fits your needs, a holistic health practitioner familiar with Premier Research Labs can help.
Many customers also learn about the brand through the founder’s original educational platform. Dr. Bob Marshall has written and lectured extensively on natural health, and his teachings remain influential among PRL users.
Buying and Quality Considerations
Premier Research Labs progesterone cream is sold through authorized online retailers, practitioner offices, and the official PRL website. Prices vary, but a 2-ounce jar typically costs between $20 and $35. Be cautious of third-party sellers that offer deep discounts, as counterfeit or expired products are possible.
Check the expiration date and the ingredient list before you buy. A legitimate product will list wild yam extract and other ingredients clearly, without vague proprietary blends for the active components. PRL is known for third-party testing, but you can always ask the seller for a certificate of analysis.
If you are new to topical hormone products, start with a small amount and monitor how your body responds. Keep a diary of any changes in mood, sleep, or skin so you can discuss them with your doctor.
Frequently Asked Questions
Is Premier Research Labs progesterone cream FDA-approved?
No. Premier Research Labs progesterone cream is sold as a dietary supplement or cosmetic, not as an FDA-approved drug. The FDA does not evaluate over-the-counter progesterone creams for treating menopause, infertility, or any other medical condition. Talk to a healthcare provider before using it for hormone-related concerns.
How do you use Premier Research Labs progesterone cream?
Most people apply a small amount, about 1/4 teaspoon, to thin-skinned areas like the inner wrists, inner arms, or thighs once or twice daily. Rotate the application site each time and follow the label directions. Many users follow a three-weeks-on, one-week-off schedule unless a doctor advises otherwise.
What are the side effects of Premier Research Labs progesterone cream?
Common side effects may include skin irritation, breast tenderness, mood changes, headaches, or bloating. Some people also notice changes in menstrual bleeding. Stop using the cream and consult a healthcare professional if you experience severe or unusual symptoms.
This page provides educational research information and does not replace medical advice, diagnosis, or treatment.