Quicksilver NAD Plus: What It Is, How to Use It, and What to Expect

Quicksilver NAD Plus is the search-friendly name for Quicksilver Scientific's liposomal NAD+ line, most often sold as NAD+ Platinum in a pump bottle that you hold under your tongue. The product delivers nicotinamide adenine dinucleotide, the same coenzyme your cells already use to make energy and repair DNA, inside phospholipid liposomes designed to survive digestion. Quicksilver NAD Plus is a dietary supplement, not an FDA-approved drug, and it is not intended to treat or cure any disease.

What Quicksilver NAD Plus Is - and What It Is Not

If you have searched what is nad plus, the short version is this: NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It carries electrons in the reactions that convert food into ATP, and it is the substrate that sirtuins and PARP enzymes use for DNA repair and cellular stress response.

Quicksilver NAD Plus is not a peptide and it is not a prescription drug. It is a supplement, and no product in this category has been shown in a large randomized trial to reverse aging in humans.

NAD+ levels do tend to fall with age in blood and tissue measurements, which is the observation that built this entire market. Whether restoring those levels changes long-term health outcomes is still unproven.

How Liposomal NAD+ Delivery Works

Plain NAD+ taken by mouth has a rough trip. It is a large, charged dinucleotide that gets broken down in the gut into smaller metabolites, mostly nicotinamide, before much of it reaches the bloodstream. That is the main reason the market for nad plus supplements is built on precursors such as NR and NMN instead of the full molecule.

Quicksilver Scientific's answer is liposomal encapsulation plus sublingual use. The liquid is held under the tongue for roughly 30 to 60 seconds, and the liposomes are designed to carry NAD+ through the oral mucosa while protecting the remainder from stomach acid.

The mechanism is plausible, and liposomal delivery is well documented for certain compounds, including some vitamins and drugs. Direct human studies measuring blood NAD+ after liposomal NAD+ are still scarce, so most of the hard evidence for raising NAD+ comes from NR and NMN trials, not from the dinucleotide itself.

Quicksilver NAD+ vs. Other NAD+ Formats

Format matters more than branding in this category. Here is how the main options compare on delivery, cost, and evidence.

Option	How it is taken	Typical cost	Human evidence for raising NAD+	Watch-outs
Liposomal liquid NAD+ (Quicksilver-style)	Sublingual liquid, 1-4 pumps daily	Roughly $70-$110 per bottle	Limited; mostly absorption rationale, few blood-level trials	Refrigeration and pump handling; premium price
Nicotinamide riboside (NR) capsules	Oral capsule, 300-1,000 mg daily	Roughly $30-$70 per month	Strongest: multiple human trials show measurable blood NAD+ increases	Mild stomach upset in some users
NMN capsules or powder	Oral, 250-1,000 mg daily	Roughly $40-$90 per month	Human trials show blood NAD+ increases	US regulatory status has been contested; buy from tested brands
IV NAD+ infusion	Intravenous drip over 2-4 hours in a clinic	Roughly $200-$1,000 or more per session	Bypasses digestion entirely and raises circulating NAD+ quickly	Must be infused slowly; chest tightness, cramping, nausea; clinician supervision required

Reported Benefits and What the Research Shows

Marketing copy talks about nad plus benefits in broad strokes. The honest version separates what has been measured from what is hoped for.

• Energy and fatigue: NAD+ sits at the center of mitochondrial energy production, so the logic is reasonable. User reports of steadier afternoon energy are common, but placebo response in supplement studies is high.
• Metabolic markers: NR and NMN trials have shown modest movement in insulin sensitivity, liver fat, and blood pressure in some small studies, with mixed results in others.
• Cognition: Small trials in older adults and in people with mild cognitive impairment have produced mixed or null results so far.
• Skin and muscle: Early studies hint at possible effects on skin elasticity and muscle function, but sample sizes are small and durations are short.

One conclusion holds up across the literature: raising NAD+ levels in the blood is achievable with precursors, but proving that this changes long-term health outcomes in humans is still an open question.

Dosing, Timing, and Practical Use

Follow the label, not a forum thread. Liposomal NAD+ products usually recommend a morning dose on an empty stomach, held under the tongue before swallowing. Some users split the dose across the day, and others cycle it on and off.

• Consistency matters more than dose escalation. A moderate daily dose taken for months tells you more than a large dose taken for a week.
• Stacking several NAD+ boosters, such as liposomal NAD+ plus NR or NMN, is popular online but not well studied. Ask a clinician before combining them.
• If you miss a dose, do not double up the next day. Restart at your normal amount.

Side Effects and Safety

Reported nad plus side effects are usually mild: nausea, headache, digestive upset, flushing, dizziness, or a temporary dip in energy. These show up more often at higher doses and with intravenous NAD+, which can also cause chest tightness and cramping and must be given slowly by a clinician.

• Talk with your doctor before use if you are pregnant, nursing, taking prescription medication, or managing a chronic condition.
• People with a history of cancer should discuss NAD+ supplementation with an oncologist, because rapidly dividing cells also rely on NAD+ pathways.
• NAD+ supplements are not FDA-approved drugs and are not reviewed for effectiveness. Third-party testing, such as NSF or USP certification, is a reasonable quality signal.

Price, Reviews, and Choosing Well

Quicksilver NAD Plus sits at the premium end of the category, largely because of the liposomal manufacturing process. If cost is the deciding factor, a well-tested NR capsule delivers more documented NAD+ elevation per dollar.

When comparing brands, check the amount per serving rather than per bottle, look for a third-party test certificate, confirm the return policy, and be skeptical of marketing that promises to reverse aging. The best nad plus supplement for most people is the one whose label they can read, whose dose they can afford to keep taking, and whose format they will actually remember to use.

COMMON QUESTIONS

Frequently Asked Questions

Is Quicksilver NAD Plus the same thing as NAD+ Platinum?

Shoppers commonly shorten Quicksilver Scientific's NAD+ line to "Quicksilver NAD Plus," and the products are sold under names like NAD+ Platinum and NAD+ Gold. Formulas and product names change over time, so always check the current label for the exact ingredient forms and amounts per serving.

Does liposomal NAD+ actually raise NAD+ levels?

There is very little published human data measuring blood NAD+ levels after taking liposomal NAD+ specifically. The strongest human evidence for raising NAD+ comes from nicotinamide riboside (NR) and NMN trials, which show measurable increases in blood NAD+ at doses of roughly 250-1,000 mg per day.

What are the side effects of NAD+ supplements?

Oral NAD+ supplements are generally well tolerated, with reported side effects limited to nausea, headache, mild digestive upset, flushing, or dizziness. Intravenous NAD+ can cause stronger reactions such as chest tightness and cramping and should only be given slowly under clinical supervision.