Sermorelin Dose: How Much to Inject, Units, and Schedules

The typical sermorelin dose is 100 to 300 micrograms (mcg) injected under the skin once daily, usually at bedtime. Most clinicians start adults at 100 to 200 mcg per night and adjust based on response, side effects, and IGF-1 levels. Sermorelin is not FDA-approved for anti-aging or weight-loss use in the United States, and compounded versions are not reviewed by the FDA for safety, purity, or potency.

Typical Sermorelin Dose Range

Sermorelin is a growth hormone–releasing hormone (GHRH) analog. It signals the pituitary to release its own growth hormone rather than delivering GH directly, which is one reason dosing stays in the microgram range instead of milligrams.

• Starting dose: 100 to 200 mcg per night
• Common maintenance dose: 200 to 300 mcg per night
• Upper end of most protocols: 300 mcg per night, with a few providers going to 500 mcg
• Frequency: nightly, or 5 nights on and 2 nights off
• Route: subcutaneous injection, usually into the abdomen or thigh

Doses above 300 mcg rarely produce better results and are more likely to cause flushing, headache, or injection-site irritation. A sermorelin starting dose should always be the lowest amount that produces a measurable IGF-1 response.

Sermorelin Dosage Chart by Vial Size

How many units of sermorelin per day depends entirely on how the vial was mixed. Sermorelin peptide dosage is measured in micrograms, but insulin syringes are marked in units. Adding more or less bacteriostatic water changes the concentration in the same vial.

Vial size	BAC water added	Concentration	Units for 200 mcg	Units for 300 mcg
2 mg	1 mL	2,000 mcg/mL	10 units	15 units
5 mg	2.5 mL	2,000 mcg/mL	10 units	15 units
10 mg	5 mL	2,000 mcg/mL	10 units	15 units
10 mg	2.5 mL	4,000 mcg/mL	5 units	7.5 units
15 mg	5 mL	3,000 mcg/mL	6.7 units	10 units

If you are searching for a sermorelin 5mg dosage or a sermorelin 10mg dosage, the vial size is not the dose. A 5 mg vial typically supplies about 25 injections at 200 mcg, and a 10 mg vial supplies roughly 50.

Always calculate your own concentration and confirm it with your prescriber or pharmacist. A miscalculated dose is the most common and most avoidable error with peptide injections.

Sermorelin Dosage in Units vs Milligrams

New users often search for how many mg of sermorelin per day, but daily amounts are measured in micrograms. A 200 mcg dose equals 0.2 mg, and a 300 mcg dose equals 0.3 mg. Numbers described as daily milligram doses are almost always vial sizes, not injection amounts.

Converting between units and micrograms uses one formula:

mcg per unit = total micrograms in the vial ÷ total units of BAC water added

Put 100 units (1 mL) of water into a 5 mg vial and each unit holds 50 mcg, so 200 mcg is 4 units. Put 250 units into that same vial and each unit holds 20 mcg, so 200 mcg is 10 units. Two people using identical vials can end up drawing very different unit volumes.

Sermorelin Injection Dosing Schedule and Timing

Sermorelin injection dosage is tied to the body's natural GH rhythm. Growth hormone release peaks during the first hours of deep sleep, so nearly all protocols inject 30 to 60 minutes before bed.

• Inject on an empty stomach — at least 2 hours after your last meal.
• Wait 30 to 60 minutes before eating, since insulin blunts the GH signal.
• Rotate injection sites to reduce lipohypertrophy.
• Refrigerate reconstituted vials and use them within 2 to 4 weeks.

Many clinics use a 5-on, 2-off sermorelin dosage schedule to mimic the body's own pulsatile pattern and limit receptor desensitization. Human data comparing continuous nightly use with cyclical use is limited, so the choice usually reflects provider preference.

Sermorelin Starting Dose and Titration

Most protocols begin at 100 mcg per night for the first one to two weeks. If side effects stay mild, the dose moves to 200 mcg and then 300 mcg, usually in 50 to 100 mcg steps every one to two weeks.

Response is tracked through symptoms, sleep quality, and bloodwork. IGF-1 is the standard marker, and providers generally aim for the middle of the age-adjusted reference range rather than the top of it. A dose that pushes IGF-1 well above normal is not considered safer or more effective.

There is no separate sermorelin dose for men in most clinical protocols. Men and women are dosed the same way, with adjustments based on side effects, IGF-1 response, age, and body weight rather than sex.

Oral Sermorelin vs Injectable Sermorelin

Oral sermorelin dosage is not a substitute for injection. Sermorelin is a 29-amino-acid peptide, and oral or sublingual forms are broken down by stomach acid and digestive enzymes before meaningful amounts reach the bloodstream.

Tablets, capsules, and sprays marketed as oral sermorelin have little reliable human pharmacokinetic data. Injectable sermorelin remains the only form in which dose-response has been studied, so treat any milligram-level oral dosing claim with skepticism.

How Sermorelin Compares to Other Peptides

Peptide	Typical dose	Half-life	Main use
Sermorelin	100–300 mcg nightly	10–20 minutes	GH release, sleep, recovery
CJC-1295 (no DAC)	100–200 mcg, 1–3x daily	~30 minutes	GH release
CJC-1295 with DAC	1–2 mg weekly	6–8 days	GH release
AOD-9604	250–500 mcg daily	~30 minutes	Fat metabolism

When comparing cjc-1295 vs sermorelin, the main difference is duration. Sermorelin mimics a natural pulse and clears quickly, while CJC-1295 with DAC stays active for days.

Some providers stack them, and one common question is can you take cjc-1295 and sermorelin together. The answer is that some off-label protocols do combine them, but large clinical trials supporting the practice do not exist.

Sermorelin vs aod 9604 is a different comparison entirely, because AOD-9604 is a fat-loss fragment of human growth hormone and does not stimulate GH release at all.

Side Effects and Safety

Common side effects include redness or stinging at the injection site, flushing, headache, and mild dizziness. More serious concerns include elevated IGF-1, fluid retention, and joint pain.

Sermorelin is generally considered to have a better safety profile than direct growth hormone injections, but it is not risk-free. Anyone with active cancer, untreated hypothyroidism, or pituitary disease should avoid it without specialist clearance. Talk to a licensed healthcare professional before starting any peptide, especially if you take insulin, thyroid medication, or corticosteroids.

COMMON QUESTIONS

Frequently Asked Questions

How many units of sermorelin should I take per day?

It depends on how your vial was reconstituted, not on a fixed number. With a 5 mg vial mixed with 2.5 mL of bacteriostatic water, a 200 mcg dose equals 10 units on a U-100 insulin syringe. Confirm your specific concentration with your prescriber or pharmacist before injecting.

Is 20 units of sermorelin too much?

It can be, depending on the concentration. In a 5 mg vial mixed with 2.5 mL of water, 20 units delivers 400 mcg — above the 100 to 300 mcg range used in most protocols. In a more dilute vial, 20 units may be closer to 200 mcg. Always calculate micrograms per unit first.

What is the starting dose of sermorelin?

Most clinicians start at 100 to 200 mcg injected subcutaneously once nightly, about 30 to 60 minutes before bed. The dose is typically increased in 50 to 100 mcg steps every one to two weeks based on side effects and IGF-1 response. Sermorelin is not FDA-approved for general anti-aging or weight-loss use in the United States.