SS-31 Dosage Chart: Research Doses, Reconstitution, and Safety

There is no FDA-approved standard dosage of SS-31 (elamipretide) for human use in the United States. Research studies have used a wide range of doses, from 1–5 mg/kg in animals to 40 mg subcutaneous daily in clinical trials. An SS-31 dosage chart is therefore a summary of research and community reports, not a medical prescription. Anyone considering SS-31 should speak with a healthcare professional first.

SS-31 is a mitochondria-targeted tetrapeptide that scientists study for mitochondrial dysfunction, heart failure, and rare genetic conditions like Barth syndrome. It is not a dietary supplement or a proven anti-aging drug. Any human use outside of a clinical trial is experimental and should be supervised by a healthcare professional.

What SS-31 Is and Why Dosing Is Not One-Size-Fits-All

SS-31, also called elamipretide, is a small peptide that concentrates in the inner mitochondrial membrane. Researchers believe it may help stabilize mitochondrial energy production, but the evidence in humans is still limited.

• Not FDA-approved: SS-31 has not received FDA approval for any human condition.
• Multiple routes: Studies use both intravenous (IV) infusions and subcutaneous (SC) injections.
• Variable doses: Doses depend on body weight, the condition being studied, and the trial design.
• Research vs. real world: A number found in a rodent study cannot be directly translated to humans.

Because of these factors, a single SS-31 dosage chart cannot cover every situation. The numbers below come from published research and public trial summaries, not from a prescribing guideline. Researchers typically report doses in milligrams per kilogram (mg/kg) for animals and in fixed milligrams for human trials.

SS-31 Dosage Chart: Reported Doses in Research

The following table compiles doses that appear in scientific literature and public trial reports. It does not recommend any dose for personal use.

Context	Route	Reported Dose	Frequency	Notes
Preclinical animal studies	Subcutaneous or intraperitoneal	1–5 mg/kg	Daily	Used to study mitochondrial function in rodents.
Clinical trial in primary mitochondrial myopathy (MMPOWER-3)	Subcutaneous	40 mg	Once daily	Phase 3 trial; did not meet its primary endpoint.
Clinical trial in heart failure	Intravenous infusion	0.05–0.1 mg/kg/h	Continuous infusion for hours	Short-term infusion in hospital settings.
Barth syndrome trial (TAZPOWER)	Subcutaneous	40 mg	Once daily	Reported in trial summaries for Barth syndrome.
Community protocols	Subcutaneous	1–5 mg per injection	Daily or several times weekly	Anecdotal; not from controlled trials.

No universal SS-31 dosage exists, and every number above comes from a specific research context. The 40 mg daily dose, for example, was tested in people with a diagnosed mitochondrial disease, not in healthy adults.

SS-31 Reconstitution and Dosage: The Math You Need

Most SS-31 vials contain 10 mg or 50 mg of lyophilized powder. You add bacteriostatic water or sterile water to dissolve the powder. The concentration depends on how much water you add.

Vial Size	Water Added	Concentration	Volume for 1 mg	Volume for 5 mg
10 mg	1 mL	10 mg/mL	0.1 mL	0.5 mL
10 mg	2 mL	5 mg/mL	0.2 mL	1.0 mL
10 mg	5 mL	2 mg/mL	0.5 mL	2.5 mL
50 mg	5 mL	10 mg/mL	0.1 mL	0.5 mL
50 mg	10 mL	5 mg/mL	0.2 mL	1.0 mL

Use this formula: dose (mg) ÷ concentration (mg/mL) = volume (mL). Understanding ss-31 reconstitution and dosage is mostly about concentration math, not a fixed number that works for everyone. Always use a new needle and syringe for each injection. Store reconstituted peptide according to the supplier's instructions, usually in a refrigerator.

What Shapes an SS-31 Dose in Practice

Several factors change how researchers and clinicians choose a dose. Most online discussions of ss-31 peptide dosage focus on subcutaneous injections because that is the route used in several trials.

• Body weight: Doses measured in mg/kg scale up or down with body weight.
• Route: IV infusions are dosed differently than subcutaneous injections.
• Condition: Trials in heart failure use different doses than trials in mitochondrial myopathy.
• Product purity: Research-grade material may contain impurities that affect safety.
• Frequency: Daily, weekly, or cyclic protocols appear in anecdotal reports.

A popular write-up like the ss-31 dosage jay campbell overview mixes trial data with personal protocols. Treat those numbers as opinion, not evidence. The same caution applies to any blog that presents a chart without citing peer-reviewed sources.

Safety, Legal Status, and What to Watch For

SS-31 is not FDA-approved for human use. It is sold as a research chemical, which means it is not regulated for purity, sterility, or dosage accuracy.

• Clinical trials have reported injection site reactions, but long-term safety in healthy people is unknown.
• Sterile technique is essential for any injection; improper handling can cause infection.
• Peptides can degrade if stored incorrectly. Follow the supplier's storage instructions.
• Never use a dosage chart as a substitute for medical advice.

Some online vendors sell SS-31 without third-party testing. That means the vial may contain less peptide than labeled or may be contaminated. If you see a commercial page such as the ss-31 peptide dosage swolverine guide, remember that it is marketing content, not a clinical guideline. The same applies to any ss 31 dosage chart you find on social media.

How to Talk to a Doctor About SS-31

If you are considering SS-31, bring the exact product information to a healthcare professional. Ask about interactions with your current medications and whether any clinical trial data applies to your condition.

1. Share the source, purity, and concentration of the product.
2. Ask whether your condition has any evidence supporting peptide use.
3. Discuss potential risks, including injection site reactions and unknown long-term effects.
4. Do not self-prescribe based on a chart you found online.

Ask whether a clinical trial is recruiting participants for your condition. That is the only way to receive SS-31 with medical oversight. SS-31 remains an investigational peptide. No dosage chart can replace personalized medical guidance.

COMMON QUESTIONS

Frequently Asked Questions

Is there a standard SS-31 dosage for humans?

No. SS-31 is not FDA-approved, so no standard human dose exists. Clinical trials have tested 40 mg subcutaneous daily and 0.05–0.1 mg/kg/h intravenous infusions, but these are experimental protocols for specific conditions.

How do you reconstitute SS-31 peptide?

Add bacteriostatic water or sterile water to the lyophilized powder. For a 10 mg vial with 2 mL of water, the concentration is 5 mg/mL. Always use sterile technique and follow the supplier's instructions.

What is the SS-31 dosage chart from Jay Campbell?

Jay Campbell is a health author who discusses peptide protocols. His SS-31 chart is a community summary, not a clinical guideline. It mixes research doses with anecdotal reports, so consult a healthcare professional before using any peptide.