CJC 1295 DAC 10 mg: A Research Guide to the Long-Acting GHRH Analog

CJC 1295 DAC 10 mg explained: how this long-acting GHRH analog works, how it differs from no-DAC versions, reconstitution math, storage, and safety.

ARTICLE OVERVIEW

CJC 1295 DAC 10 mg explained: how this long-acting GHRH analog works, how it differs from no-DAC versions, reconstitution math, storage, and safety.

CJC 1295 DAC 10 mg is a single 10-milligram vial of CJC-1295 with drug affinity complex, a long-acting growth hormone-releasing hormone (GHRH) analog sold strictly for laboratory research. The 10 mg size holds about ten times the material of a 1 mg vial, so it is normally reconstituted with a larger volume of bacteriostatic water and divided into many research aliquots. CJC-1295 DAC is not FDA-approved for human use, and this article is educational information rather than medical advice.

What Is CJC 1295 DAC 10 mg?

CJC-1295 is a synthetic 30-amino-acid peptide engineered from human GHRH. Attaching the DAC (drug affinity complex) group lets the peptide bind covalently to serum albumin after injection, which slows clearance and stretches its activity window from minutes to days.

That albumin binding is the defining feature of the "with DAC" version. Unmodified GHRH is broken down within minutes, while CJC-1295 DAC circulates for roughly six to eight days in published human pharmacokinetic work. The result is a sustained, relatively flat rise in growth hormone and IGF-1 rather than the sharp pulses the body produces naturally.

Why researchers choose the 10 mg vial

A cjc 1295 dac 2 mg vial suits short pilot work, while the 10 mg format costs less per milligram and fits multi-week protocols that pull repeatedly from one lot. Fewer lots mean fewer batch-to-batch variables, which matters when a study runs for months.

Keep the trade-off in mind: reconstituted peptide loses potency over time, so a large vial is only an advantage if the material will be used before it degrades.

CJC-1295 DAC vs No DAC: How the Two Versions Compare

Two peptides share the CJC-1295 name: the DAC version and the short-acting version often sold as cjc-1295 without dac, also called Mod GRF 1-29. They share the same core sequence but behave very differently once in circulation.

FeatureCJC-1295 with DACCJC-1295 without DAC
Half-lifeApproximately 6-8 daysApproximately 30 minutes
Albumin bindingYes, covalentNo
Typical research dosing frequencyOnce weeklyOne to three times daily
Approximate molecular weight3,647 Da3,368 Da
Growth hormone patternSustained elevationShort, pulse-like spike
Common vial sizes2 mg, 5 mg, 10 mg2 mg, 5 mg, 10 mg

Researchers comparing cjc-1295 dac vs no dac usually weigh convenience against physiological realism. The DAC version requires one injection per week but produces a constant signal that does not resemble natural secretion. The no-DAC version clears quickly and generates brief pulses closer to normal pulsatility, at the cost of more frequent administration.

CJC-1295 With DAC Dosage Reported in Research

The figures below come from published studies and research literature. They are not a recommendation for human use.

In the largest published human trial of the long-acting peptide, subcutaneous CJC-1295 DAC was given at 30 or 60 micrograms per kilogram once weekly for six weeks. For a 70 kg subject that equals roughly 2.1 mg to 4.2 mg weekly, which is why a 10 mg vial covers a multi-week protocol.

Many research write-ups round to a flat cjc-1295 with dac dosage of 1 mg to 2 mg once per week, although no consensus standard exists. Published trials tracked IGF-1, fasting glucose, and heart rate as the main safety markers.

Protocols using the short-acting peptide look different. A commonly discussed cjc-1295 no dac dosage is 100 micrograms per administration, given two or three times daily, often alongside a ghrelin-pathway peptide such as ipamorelin or GHRP-2.

Reconstituting and Storing a 10 mg Vial

Reconstitution is simple arithmetic: divide 10 mg by the milliliters of diluent you add. The table below shows the concentrations researchers use most often.

Bacteriostatic water addedConcentrationVolume for a 100 mcg drawVolume for a 1 mg draw
1 mL10 mg/mL0.01 mL0.1 mL
2 mL5 mg/mL0.02 mL0.2 mL
5 mL2 mg/mL0.05 mL0.5 mL
10 mL1 mg/mL0.10 mL1.0 mL

Aim the stream at the glass wall rather than the powder, then swirl or roll the vial gently. Do not shake it, because foaming and shear forces can damage the peptide.

Storage rules that protect potency

  • Lyophilized powder: store at -20°C or colder, protected from light.
  • Reconstituted peptide: refrigerate at 2-8°C and use within a few weeks.
  • Avoid repeated freeze-thaw cycles, which degrade the peptide faster than steady refrigeration.
  • Swab the rubber stopper with alcohol before every draw.

Legality, Safety, and Sourcing

CJC-1295 DAC is not approved by the FDA for human use in the United States. It is sold as a research chemical, and vendors that market it for injection into people are operating outside the labeling permitted for such products.

Reported effects in published trials included injection-site irritation, transient flushing, and small increases in heart rate, alongside rises in IGF-1 and blood glucose. Long-term safety data in healthy adults remain limited, and sustained IGF-1 elevation is a biomarker researchers monitor closely.

Anyone considering use should speak with a licensed healthcare professional first, particularly people with diabetes, a cancer history, or pituitary conditions. Buying from an unverified supplier adds a second risk: purity and actual peptide content vary widely between vendors, and a 10 mg label does not guarantee 10 mg of peptide.

Questions to ask before ordering

  1. Does the vendor publish a third-party certificate of analysis with HPLC and mass spectrometry results?
  2. Does the batch number on the label match that report?
  3. Is the product labeled explicitly for laboratory research and not for human consumption?

CJC-1295 DAC 10 mg is a bulk research format best suited to extended laboratory work with careful cold storage. No peptide sold as a research chemical should be treated as a treatment, a cure, or a substitute for medical care.

Frequently Asked Questions

What is CJC 1295 DAC 10 mg used for?

It is a 10 mg research vial of CJC-1295 with DAC, a long-acting GHRH analog used in laboratory study of growth hormone and IGF-1 signaling. It is sold for research purposes only and is not FDA-approved for any human medical use.

How long does CJC-1295 DAC stay active in the body?

Published human pharmacokinetic data report a half-life of roughly six to eight days because the DAC group binds covalently to serum albumin. That extended window is why research protocols usually describe once-weekly administration instead of daily injections.

How much bacteriostatic water should I add to a CJC-1295 DAC 10 mg vial?

Adding 2 mL of bacteriostatic water yields a concentration of 5 mg/mL, so a 1 mg draw measures 0.2 mL. Adding 5 mL yields 2 mg/mL. Let the water run down the vial wall and swirl gently rather than shaking, then refrigerate the reconstituted peptide at 2-8°C.

Research information notice

This page provides educational research information and does not replace medical advice, diagnosis, or treatment.