CJC-1295 w DAC 5mg is a long-acting research peptide. Learn what the 5mg vial contains, how reconstitution works, and typical dosing ranges for researchers.
CJC-1295 w DAC 5mg is a five-milligram lyophilized vial of a long-acting growth hormone-releasing hormone (GHRH) analog, and the w DAC notation means the peptide carries a Drug Affinity Complex that binds it to albumin in circulation. That albumin binding stretches the peptide's half-life from roughly 30 minutes to about six to eight days in published human pharmacokinetic studies. The material is sold as a research chemical, and no regulatory agency has approved CJC-1295 for human use.
Suppliers sometimes list the same product as cjc 1295 dac 5mg, so the two labels describe one item. Five milligrams is a popular size because it holds enough powder for a multi-week study while still reconstituting easily in a single standard vial.
What the DAC Modification Changes
CJC-1295 is a synthetic analog of GHRH(1-29) with four amino acid substitutions that resist enzymatic degradation. The DAC version adds a linker that forms a covalent bond with serum albumin after injection. Albumin then acts as a carrier protein, slowing clearance and producing a sustained rather than pulsatile signal.
That difference shapes study design. A compound that stays active for a week creates a very different endocrine profile than one cleared in half an hour, and published trials report IGF-1 elevations that persist for several days after a single administration.
CJC-1295 With DAC vs. Without DAC
| Feature | CJC-1295 with DAC | CJC-1295 without DAC (Mod GRF 1-29) |
|---|---|---|
| Approximate half-life | 6-8 days | About 30 minutes |
| Albumin binding | Yes, through the DAC linker | No |
| Molecular weight | About 3,647 Da | About 3,358 Da |
| Typical research frequency | Once weekly | Two to three times daily |
| Growth hormone release pattern | Sustained elevation | Short pulses |
Researchers comparing cjc 1295 with dac 5mg to the no-DAC analog should remember that the two peptides are not interchangeable milligram for milligram, because the added linker changes both the molecular weight and the pharmacokinetics.
Reconstitution and Mixing
The cjc-1295 dac 5mg reconstitution step is where most handling errors happen. Lyophilized peptides are fragile, and spraying water directly onto the powder cake can shear the protein and lower recovery.
- Let the vial and the diluent come to room temperature.
- Swab both stoppers with an alcohol pad and allow them to dry.
- Draw the chosen volume of bacteriostatic water and aim the stream at the glass wall, not the powder.
- Swirl gently until the powder dissolves completely. Never shake the vial.
- Write the date and final concentration on the label and store the vial upright.
Standard cjc 1295 dac 5mg mixing instructions call for 1 mL to 2.5 mL of bacteriostatic water, depending on the concentration a protocol requires. Preservative-free sterile water also works, but the resulting solution has a shorter usable life.
| Water added | Concentration | Peptide in 10 units (0.1 mL) |
|---|---|---|
| 1 mL | 5 mg/mL | 500 mcg |
| 2 mL | 2.5 mg/mL | 250 mcg |
| 2.5 mL | 2 mg/mL | 200 mcg |
| 5 mL | 1 mg/mL | 100 mcg |
Dosing Reported in the Literature
There is no FDA-approved cjc-1295 with dac 5mg dosage for humans, so every figure below is a research reference rather than a clinical recommendation. Early human studies used single subcutaneous doses of 30 to 60 mcg/kg and recorded IGF-1 increases lasting up to six days.
| Study dose | Approx. amount for a 70 kg subject | Approx. amount for a 90 kg subject |
|---|---|---|
| 30 mcg/kg | 2.1 mg | 2.7 mg |
| 45 mcg/kg | 3.2 mg | 4.1 mg |
| 60 mcg/kg | 4.2 mg | 5.4 mg |
Online community protocols usually describe lower weekly totals, often 1 to 2 mg per week split across two injections. Those numbers come from user reports rather than controlled trials and vary considerably between sources.
Storage and Stability
Lyophilized CJC-1295 w DAC powder tolerates short periods at room temperature during shipping, but long-term storage should be at -20°C. Once reconstituted, the vial belongs in a refrigerator at 2 to 8°C and away from light.
Most suppliers recommend using a reconstituted vial within four to six weeks, and many researchers stay closer to four weeks. Repeated freeze-thaw cycles break peptides down and should be avoided.
What to Check Before You Buy
A legitimate 5mg vial should arrive with a batch number and a third-party certificate of analysis that lists purity by HPLC and identity by mass spectrometry. Purity above 98% is a reasonable benchmark for research-grade peptide. If a vendor cannot supply documentation, the contents of the vial cannot be verified.
Cold-chain shipping matters most for products that are already in solution, since lyophilized powder is far more forgiving. Standard packaging for CJC-1295 w DAC 5mg is a clear or amber glass vial with a rubber stopper and an aluminum crimp seal.
Safety, Sourcing, and Legal Status
CJC-1295 is not FDA-approved for human use in the United States, and 5mg vials sold online carry for-research-use-only labels. Effects reported with unsupervised use include injection-site irritation, flushing, headache, fluid retention, and shifts in blood glucose or IGF-1 levels.
Anyone weighing personal use should speak with a healthcare professional and consider baseline bloodwork instead of relying on forum anecdotes. Vendor quality varies widely, and an independent certificate of analysis is the most reliable way to confirm a vial's identity and purity.
Frequently Asked Questions
How much bacteriostatic water do I add to a 5mg CJC-1295 with DAC vial?
Most researchers add 1 mL to 2.5 mL of bacteriostatic water. Adding 1 mL produces a 5 mg/mL solution, 2 mL produces 2.5 mg/mL, and 2.5 mL produces 2 mg/mL, which makes syringe math simpler. Aim the water at the glass wall, swirl gently, and never shake the vial.
How long is CJC-1295 w DAC stable after reconstitution?
A reconstituted vial should be refrigerated at 2 to 8°C and protected from light. Most suppliers suggest using it within four to six weeks, and many researchers discard it after about four weeks. Repeated freeze-thaw cycles degrade the peptide and should be avoided.
Is CJC-1295 w DAC the same as CJC-1295 without DAC?
No. The DAC version binds to albumin and has a half-life of roughly six to eight days, while the version without DAC is cleared in about 30 minutes. The two are studied and handled differently, and neither is FDA-approved for human use.
This page provides educational research information and does not replace medical advice, diagnosis, or treatment.