MOTS-c is a mitochondrial-derived peptide studied in metabolic signaling and exercise biology. Browse its identity, evidence, comparisons, and handling research.
MOTS-c means mitochondrial open reading frame of the 12S rRNA type-c. The name identifies a mitochondrial-derived peptide, not a marketed medicine.
MOTS-c is a short peptide associated with a mitochondrial DNA coding region. Endogenous peptide measurements and externally administered research materials are different contexts.
Research examines cellular energy sensing, metabolic stress responses, and pathways including AMPK. Mechanistic findings depend on the experimental model and exposure.
Published work includes cell and animal experiments and human measurements around exercise. Changes in endogenous MOTS-c do not establish benefits from administering it.
FDA identifies missing human safety information and potential characterization and immunogenicity concerns for compounded MOTS-c. Clinical effectiveness cannot be inferred from preclinical mechanisms.
MOTS-c research connects mitochondrial signaling with metabolic adaptation. A 2021 study measured exercise-associated endogenous MOTS-c in humans and investigated muscle and physical-performance responses in mice. The human observations and mouse administration experiments answer different questions; neither should be presented as a controlled human treatment result. Exercise and muscle-homeostasis study (2021)
A separate human exercise study examined circulating mitochondrial-derived peptides and reported different responses across peptides and exercise conditions. Together, these studies support investigating endogenous stress responses, while leaving the effects of externally administered MOTS-c unresolved. Human exercise study (2021)
ClinicalTrials.gov lists MOTS-MET (NCT07505745), a sponsor-submitted Phase 2 study of MOTS-c in adults with prediabetes and overweight or obesity. The retrieved record is recruiting, with estimated enrollment of 120 and no posted results. This is a registered research program, not evidence of clinical benefit or FDA approval. MOTS-MET registry record
FDA describes missing human exposure and safety information for compounded MOTS-c, alongside peptide-impurity and characterization concerns. This category distinguishes biological research from evidence for a particular formulation or clinical use. FDA compounding safety information
Current programs, research areas, study status, enrollment, and expected completion dates organized from primary registry records.
Prediabetes · Insulin Resistance · Overweight/Obesity
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